My work examines the ways in which plague prevention practices and plague-related public health measures condition both theatrical and cultural space within early modern England. As theatre offers a locus for sharing the human experience, creative interactions with early modern plague prevention methods and models may offer crucial insights into how plague driven socio-spatial orders were understood, assimilated, and experienced. These latent experiences will be engaged with through examining the applied prophylactic practices within three distinct early modern spaces; The Body, The Home, and The Community to discover how such measures reoriented the social and spatial paradigms within the work of Shakespeare and his contemporaries. As a result, my research also begins to assess the cultural impact of early modern plague-time spatial ordering beyond the walls of the playhouse, and imagines how the applied material and sensory prophylaxes galvanised space between people, places, and objects within wider culture during outbreaks of the disease. My aim is to explore these dramatic articulations of plague-time space as alert and critical models of contemporary prophylactic practice and as extant cultural records of a largely undocumented early modern experience. Subsequently, my research will not only further illustrate the importance of early modern theatre as a store of cultural memory and emotive engagement, but it also hopes to invite new debates within the field of medical humanities and theatre history by considering the historical dynamic between disease prevention and human creativity which, in light of our own pandemic experiences, is a timely and important pursuit.